The average Profiles of real Data match Gene Expression simulated by the reprogramming Ising Model (a) The genetic state of each node at each cell cycle in reprogramming Ising model. Neighbor in the same level, other lineage in level 4 and upper neighbor are relative to the initial somatic cell. (b) The standardized average profiles of gene expression in each cluster at each time point or in partially reprogrammed cells. Genes in each node can be assigned to a cluster by similar gene expression pattern. Upper left, first cluster. Upper right, second cluster. Lower left, third cluster. Lower right, fourth cluster.
Hu et al. BMC Systems Biology 2011 5(Suppl 2):S8 doi:10.1186/1752-0509-5-S2-S8