Candidate commonly binding transcription factors. Using Pscan, 50 top-ranked N-MEG+ and N-MEG0→1+ were analysed in their upstream sequences. In N-MEG+, transcription factors involved in serum response activities have been identified. In N-MEG0→1+, IRF1-IRF2 mediated tumor suppressing pathways were identified as candidate driving pathways.
Kim et al. BMC Systems Biology 2011 5(Suppl 2):S4 doi:10.1186/1752-0509-5-S2-S4