Table 1

Rate expressions and parameters

Rate

Rate expression

Parameters


Association of TNF to the receptor TNF-R,

kon = 9.09 × 10-5 nM-1s-1

Dissociation of TNF,

koff= 1.00 × 10-4s-1

Activation of Casp8 through DISC,

v1 = 2.65 × 10-3s-1

K1 = K2 = 50nM

Activation of Casp3 directly,

v2 = 6.00 × 10-5nM-1s-1

Activation of Casp3 through mitochondria,

v3 = 2.60 × 10-4s-1

[Casp9]0 = 20nM

K3 = 8nM

τ = 30min

Synthesis rate

vCasp8 = 6.67 × 10-4nMs-1

vCasp3 = 4.00 × 10-5nMs-1

Degradation rate

dcasp8 = 2.00 × 10-5s-1

dcasp3 = 2.00 × 10-7s-1

dCasp3* = 2.40 × 10-4s-1


Gu et al. BMC Systems Biology 2011 5(Suppl 1):S13   doi:10.1186/1752-0509-5-S1-S13

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