Figure 3.

Model simulation results for caspase activities Model simulation results for pro-caspase-8 (A), pro-caspase-3 (B), caspase-8 (C) and caspase-3(D). In (A) and (B), the experimental data (circle dots) are retrieved from [12], Fig. 3, which include time courses for pro-caspase-8 and -3 in Jurkat cells in the presence of 100ng/ml FasL at room temperature. In the simulation, [TNF] was set to 2.0nM to mimic the stimuli associated with 100ng/ml FasL [12]. The total concentration of FasL receptor was also set to [TNF-R]₀ = 10.0nM according to [12].