A model for TNF signaling-induced apoptosis An illustrated model of apoptosis induced by TNF signaling. TNF signaling induces the formation of membrane-bound death inducing signaling complexes (DISC), which subsequently recruit pro-caspase-8 and activate it by proteolytic cleavage. The active caspase-8 then cleaves various intracellular proteins, including pro-caspase-3, which results in caspase-3 activation and triggering of the cell death program. Caspase-8 cleavage of caspase-3 can occur through two separate pathways, either directly or indirectly, via mitochondria and caspase-9.
Gu et al. BMC Systems Biology 2011 5(Suppl 1):S13 doi:10.1186/1752-0509-5-S1-S13