Table 1

Proteins identified as members of the "central core of cervical cancer".

Accession number

Name

Score

Expect

Searched-Matched

Coverage


GRP78_HUMAN

78 kDa glucose-regulated protein

391

1.60E-035

91 - 46

58%

ENOA_HUMAN

Alpha-enolase

327

4.00E-029

82 - 34

82%

GRP78_HUMAN

79 kDa glucose-regulated protein

302

1.30E-026

64 - 32

47%

HSP7C_HUMAN

Heat shock cognate 71 kDa protein

294

8.10E-026

70 - 39

48%

VIME_HUMAN

Vimentin

290

2.00E-025

64 - 33

63%

ENOA_HUMAN

Alpha-enolase

286

5.10E-025

82 - 34

82%

PDIA1_HUMAN

Protein disulfide-isomerase

252

1.30E-021

77 - 30

55%

ANXA2_HUMAN

Annexin A2

249

2.60E-021

65 - 31

72%

TBB5_HUMAN

Tubulin beta chain

247

4.00E-021

73 - 32

62%

ANXA4_HUMAN

Annexin A4

233

1.00E-019

50 - 25

59%

EFTU_HUMAN

Elongation factor Tu, mitochondrial

217

4.00E-018

44 - 22

52%

TPIS_HUMAN

Triosephosphate isomerase

206

5.10E-017

42 - 17

69%

VIME_HUMAN

Vimentin

206

5.10E-017

62 - 23

50%

PGAM1_HUMAN

Phosphoglycerate mutase 1

205

2.10E-016

41 - 18

58%

ATPB_HUMAN

ATP synthase subunit beta, mitochondrial

193

1.00E-015

84 - 44

72%

ACTG_HUMAN

Actin, cytoplasmic 2

192

1.30E-014

50 - 20

48%

PUR9_HUMAN

Bifunctional purine biosynthesis protein PURH

191

1.60E-015

49 - 22

45%

KCRB_HUMAN

Creatine kinase B-type

178

3.20E-014

50 - 19

48%

EF2_HUMAN

Elongation factor 2

154

8.10E-012

67 - 26

33%

HYOU1_HUMAN

Hypoxia up-regulated protein 1

154

8.10E-012

38 - 19

22%

KCRB_HUMAN

Creatine kinase B-type

154

8.10E-012

50 - 19

48%

PPIA_HUMAN

Peptidyl-prolyl cis-trans isomerase A

150

2.00E-011

45 - 16

81%

GELS_HUMAN

Gelsolin

147

4.00E-011

46 - 19

30%

VINC_HUMAN

Vinculin

145

6.40E-011

36-19

20%

WDR1_HUMAN

WD repeat-containing protein 1

144

8.10E-011

46 - 16

31%

EZRI_HUMAN

Ezrin

131

1.60E-009

60 - 26

34%

HSP71_HUMAN

Heat shock 70 kDa protein 1A/1B

129

2.60E-009

42 - 21

33%

TBA1C_HUMAN

Tubulin alpha-1C chain

127

4.00E-009

45 - 13

37%

PRDX1_HUMAN

Peroxiredoxin-1

126

5.10E-009

53 - 18

58%

PDIA3_HUMAN

Protein disulfide-isomerase A3

125

6.40E-009

47 - 15

28%

GRP75_HUMAN

Stress-70 protein, mitochondrial

123

1.00E-008

81 - 34

43%

DHSA_HUMAN

Succinate dehydrogenase flavoprotein subunit

122

3.30E-007

39 - 17

21%

RSSA_HUMAN

40S ribosomal protein SA

121

1.60E-008

37 - 11

34%

HS90B_HUMAN

Heat shock protein HSP 90-beta

119

2.6e-08

44 - 19

27%

ESTD_HUMAN

S-formylglutathione hydrolase

114

8.10E-008

25 - 11

41%

TKT_HUMAN

Transketolase

114

8.10E-008

52 - 19

32%

LDHB_HUMAN

L-lactate dehydrogenase B chain

112

1.30E-007

43 - 20

36%

AL1A1_HUMAN

Retinal dehydrogenase 1

110

2.00E-007

58 - 19

34%

IPYR_HUMAN

Inorganic pyrophosphatase

110

2.00E-007

22 - 9

35%

DDX3X_HUMAN

ATP-dependent RNA helicase DDX3X

108

3.20E-007

23 - 13

20%

DHE3_HUMAN

Glutamate dehydrogenase 1, mitochondrial

107

4.00E-007

38 - 13

29%

G3P_HUMAN

Glyceraldehyde-3-phosphate dehydrogenase

107

4.00E-007

55 - 13

42%

ACON_HUMAN

Aconitate hydratase, mitochondrial

105

6.40E-007

54 - 23

30%

ML12A_HUMAN

Myosin regulatory light chain 12A

105

6.40E-007

32 - 11

63%

RIR1_HUMAN

Ribonucleoside-diphosphate reductase large subunit

101

1.60E-006

28 - 15

18%

EF2_HUMAN

Elongation factor 2

99

2.60E-006

60-20

29%

QCR1_HUMAN

Cytochrome b-c1 complex subunit 1, mitochondrial

98

3.30E-006

45 - 15

29%

CNN2_HUMAN

Calponin-2

96

4.50E-006

51 - 13

48%

PCBP1_HUMAN

Poly(rC)-binding protein 1

94

8.30E-006

39 - 14

44%

IMMT_HUMAN

Mitochondrial inner membrane protein

92

1.30E-005

34 - 13

20%

CAPG_HUMAN

Macrophage capping protein

91

1.80E-005

41 - 11

30%

TCTP_HUMAN

Translationally-controlled tumor protein

91

1.80E-005

19 - 8

40%

PSB4_HUMAN

Proteasome subunit beta type-4

89

1.70E-003

20 - 7

34%

TERA_HUMAN

Transitional endoplasmic reticulum ATPase

88

3.10E-005

49 - 15

21%

K2C1_HUMAN

Keratin, type II cytoskeletal 1

87

3.70E-005

46 - 13

29%

LEG1_HUMAN

Galectin-1

84

7.70E-005

41 - 8

51%

1433Z_HUMAN

14-3-3 protein zeta/delta

80

2.30E-004

43 - 14

54%

LMNA_HUMAN

Prelamin-A/C

78

3.40E-004

37 - 11

22%

HNRPL_HUMAN

Heterogeneous nuclear ribonucleoprotein L

77

4.10E-004

27 - 13

16%

TCPH_HUMAN

T-complex protein 1 subunit eta

77

4.00E-004

36 - 15

30%

OSBL8_HUMAN

Oxysterol-binding protein-related protein 8

73

1.10E-003

56 - 13

21%

TCPE_HUMAN

T-complex protein 1 subunit epsilon

71

1.70E-003

30 - 11

23%

HYOU1_HUMAN

Hypoxia up-regulated protein 1

70

2.20E-003

28 - 13

14%

PSA5_HUMAN

Proteasome subunit alpha type-5

69

2.70E-003

17 - 6

25%

FOXP3_HUMAN

Forkhead box protein P3

68

3.40E-003

41 - 12

34%


The entry name corresponds to the UniProt database, the score and expect value were obtained from the search engine Mascot. The expect value is the number of matches with equal or better scores that are expected to occur by chance alone. Score as -10*LOG10(P), where P is the absolute probability. The lower the expectation value, the more significant the score.

Higareda-Almaraz et al. BMC Systems Biology 2011 5:96   doi:10.1186/1752-0509-5-96

Open Data