Figure 9.

Two-drug interactions. The figure shows an evaluation of the model-predicted ATP-levels of A549 and AG02603 when the concentrations of two drugs are held constant while the concentration of the other two drugs are varied. The first and third columns (A) and (C) correspond to ATP levels of AG02603 in response to variations in different pairs of drug. The concentrations of the other two drugs are fixed at zero for column (A) and a selected combination (Table 3) for column (C). The second and fourth columns (B) and (D) correspond to ATP levels of A549 in response to variations in different pairs of drug (rows). The concentrations of the other two drugs are fixed at zero for column (B) and a selected combination (Table 3) for column (D). The figure shows that at the selected combination, the difference between the response surface of AG02603 and A549 is significantly higher than when the difference at zero concentrations.

Al-Shyoukh et al. BMC Systems Biology 2011 5:88   doi:10.1186/1752-0509-5-88
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