Additional file 2.

Supplemental Tables. Supplemental Table S1 lists contributions of seed domain-disease associations (leave-one-out cross-validation experiments using the large domain-domain interaction network). Supplemental Table S2 lists contributions of seed domain-disease associations (ab initio prediction experiments using the small domain-domain interaction network). Supplemental Table S3 lists contributions of seed domain-disease associations (ab initio prediction experiments using the large domain-domain interaction network). Supplemental Table S4 lists the genome-wide evidence of associations between domains and type 1 diabetes. Supplemental Table S5 lists the genome-wide evidence of associations between domains and type 2 diabetes. Supplemental Table S6 lists the genome-wide evidence of associations between domains and Crohn's disease. Supplemental Table S7 lists the genome-wide evidence of associations between domains and breast cancer. Supplemental Table S8 lists contributions of seed domain-disease associations in the analysis of the four disease examples.

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Zhang et al. BMC Systems Biology 2011 5:55   doi:10.1186/1752-0509-5-55