Effect of rebinding on receptor occupation at equilibrium. A) Comparison of dose response curves between n = 1 and n = 20 when ligand is dropped at the edge of affinity surface when unbound (solid lines - standard simulations) or ligand randomly reinjected in bulk when unbound (dashed lines). B) Black bars: ratio obtained with the same layout but using E50 obtained with random reinjection normalized by E50 obtained with normal reinjection. White bars: ratio obtained for random reinjection using EC50 computed for various cluster sizes normalized by E50 with no clusters (n = 1).
Caré and Soula BMC Systems Biology 2011 5:48 doi:10.1186/1752-0509-5-48