Results on the immune response network. (a) The expanded host immune response network. (b) The shortest elementary signaling mode in this network. (c) Importance values of nodes in this network obtained by single-node deletions. (d) Prediction accuracy. Bt: bacteria, EC: Epithelial cells, PIC: Pro-inflammatory cytokines, Th1RC: T helper cell type 1 related cytokines, Th2RC: T helper cell type 2 related cytokines, DC: Dendritic cells, T0: T0 cells, Th1C: T helper cell type 1, Th2C: T helper cell type 2, MP: Macrophages, BC: Antibody-producing B cells, Cab: Complement-fixing antibodies, Oab: Other antibodies, AgAb: Antigen-antibody complex, RP: Recruited PMNs, Cp: Complement, AP: Activated phagocytes, PH: Phagocytosis. In (a) and (b), composite nodes are represented by small gray solid circles, original nodes and complementary nodes are represented by rectangles. The labels of complementary nodes are denoted by the labels for the corresponding original nodes prefixed by the symbol '~'. The color coding of the nodes in (b) indicates the level of their participation in the 15 ESMs of the network. In (c) and (d), triangles represent the importance values or prediction accuracy obtained by the ESM measure, circles represent the simple path measure, plus signs denote the SigFlux measure, and crosses show the betweenness centrality measure.
Wang and Albert BMC Systems Biology 2011 5:44 doi:10.1186/1752-0509-5-44