Selected causative genes in the hippocampus found using network edge orienting. A) Model fitted by NEO software implicates a marker (DNA) as causal for a phenotypic trait through expression of a gene (RNA) B) Thresholds for FDR < 5% shown as red horizontal lines. Vertical black lines indicate the start position of the gene. 6330503K22RIK, Rps15a, Kif3a, and Stard7 are genes with local markers that perturb gene expression levels, which in turn contribute to fear phenotypes.
Park et al. BMC Systems Biology 2011 5:43 doi:10.1186/1752-0509-5-43