Fear conditioning in the HMDP. A) Behavioral procedure for cued fear conditioning. Mice were subjected to a three-phase procedure. On day 1, mice received 3 auditory conditional stimuli (CS) co-terminating with 0.75 mA foot shock. On day 2, mice were returned to the conditioning chamber for an 8 minute extinction test. On day 3, mice were placed in a novel chamber and given a series of 10 CS presentations (inter-trial interval 1 minute). Green horizontal lines show time periods when fear endpoints were measured. B) Behavioral distributions for selected endpoints across HMDP, corresponding to panels in A. Percent immobility calculated for three separate test phases.
Park et al. BMC Systems Biology 2011 5:43 doi:10.1186/1752-0509-5-43