A systems biology approach to dissecting fear biology. Data from behavioral phenotype analysis was integrated with SNP genotypes to map behavioral QTLs. Behavioral phenotypes were also compared to gene co-expression modules created from hippocampus and striatum microarray datasets. Gene expression data and SNP genotypes were used together to map expression QTLs. All three datasets were merged to prioritize mapped genes using Network Edge Orienting. This approach identifies gene networks associated with behavioral phenotypes.
Park et al. BMC Systems Biology 2011 5:43 doi:10.1186/1752-0509-5-43