Figure 8.

Network connecting inflammation with central metabolism. A) Individual nodes (compounds and proteins) are connected based on the shortest path algorithm. The initial compounds and proteins (marked in yellow) have been selected based on their involvement in pathways detected by PCA-pathway analysis and their significantly different concentration/activity in the COPD or training specific literature. Proteins and compounds are connected by following all possible relations within the COPD knowledge network which results in the most parsimonious network revealing a putative mechanistic connection between inflammation related processes and the central metabolism. B) Visualisation of a disease specific pathway association as a proxy for possible protein importance in a disease mechanism. Each protein in the network is queried for the number of associated disease specific pathways manually curated from the literature into the knowledge base. Numbers are visualised from light red (view pathways) to deep red (high number of pathways associated).