BMC Systems Biology

official impact factor 3.57

Open Access Highly Access Software

Knowledge management for systems biology a general and visually driven framework applied to translational medicine

Dieter Maier1*, Wenzel Kalus1, Martin Wolff1, Susana G Kalko2, Josep Roca2, Igor Marin de Mas4, Nil Turan3, Marta Cascante4, Francesco Falciani3, Miguel Hernandez5, Jordi Villà-Freixa5 and Sascha Losko1

Author Affiliations

1 Biomax Informatics AG, Planegg, Germany

2 Hospital Clinic-IDIBAPS-CIBERES, Universitat de Barcelona, Barcelona, Spain

3 School of Biosciences and Institute of Biomedical Research (IBR), University of Birmingham, Birmingham, UK

4 Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina at Universitat de Barcelona IBUB and IDIBAPS-Hospital Clinic, Barcelona, Spain

5 Computational Biochemistry and Biophysics lab, Research Unit on Biomedical Informatics (GRIB) of IMIM/UPF, Parc de Recerca Biomdica de Barcelona (PRBB); Barcelona, Spain

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BMC Systems Biology 2011, 5:38 doi:10.1186/1752-0509-5-38

Published: 5 March 2011

Additional files

Additional file 1:

XML export of the full COPD knowledge base data model containing all semantic objects, annotation and experiment definitions.

Format: XML Size: 611KB Download file

Open Data

Additional file 2:

Table of existing mapping scripts and wrappers.

Format: CSV Size: 1KB Download file

Open Data

Additional file 3:

Step-by-step tutorial to access and query the COPD specific BioXM instance set-up as part of the BioBridge project.

Format: PDF Size: 1.6MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

A set of Affymetrix probes used within the Step-by-step tutorial.

Format: TXT Size: 238KB Download file

Open Data

Additional file 5:

R script for pathway level principal component analysis of expression data integrated into BioXM and used as part of the analysis described in the Step-by-step tutorial.

Format: R Size: 5KB Download file

Open Data

Additional file 6:

R script for significance testing of differentially regulated pathways identified by principal component analysis integrated into BioXM and used as part of the analysis described in the Step-by-step tutorial.

Format: R Size: 1KB Download file

Open Data

Additional file 7:

Analysis of the sub-network connecting inflammation to central metabolism which is derived from the overall COPD knowledge network based on shortest path network search.

Format: PDF Size: 354KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data