Resolution:
## Figure 5.
Systematic evaluation of partial correlation coefficients versus pathway distances. Dashed lines in A and B indicate a significance level of 0.01 with Bonferroni correction.
A: Pathway distances from our consensus model against partial correlation coefficients
for the five lipid-based metabolite classes in our data set. We observe an enrichment
of significant partial correlations for a pathway distance of one, which rapidly drops
for an increasing number of pathway steps. B: Comparison of partial correlation coefficients and Pearson correlation coefficients.
Pearson correlation coefficients are generally high, independent of the actual pathway
distance, indicating for systemic coregulation effects throughout the lipid metabolism.
C: Wilcoxon rank sum test p-values between the partial correlation distributions of directly
and indirectly connected pairs, and sensitivity/specificity/Fvalues measuring the discriminatory power to distinguish direct from indirect pairs.
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