Table 1 |
|||||
|
Data sets included in the host response compendium |
|||||
|
Virus |
Virus strain |
Mouse strain |
Time points* |
Outcome |
Reference |
|
|
|||||
|
Influenza A H1N1 |
r1918, 2:6 r1918 (1918 HA, NA in Tx91), 5:3 r1918 (1918 HA, NA, M, NP, S in Tx91), Tx91 (A/Texas/36/91) |
BALB/c |
1, 3, 5 dpi |
0% survival (with r1918, 2:6 r1918, 5:3 r1918), 100% survival (with Tx91) |
Kash 2006 [30], Tumpey 2005 (for outcome data)[31] |
|
Influenza A H1N1 |
r1918, PR8 |
C57BL/6 |
1, 3, 5 dpi |
0% survival (with r1918), 65% survival (with PR8) |
Goodman 2009 [32] |
|
Influenza A H3N2 |
HKx31 (A/HKx31) |
BABL/c, C57BL/6 |
30 hpi |
45% survival (in BALB/c), 80% survival (in C57BL/6) |
|
|
Influenza A H5N1 |
HK213 (A/Hong Kong/213/03) |
C57BL/6, DBA/2J, |
3 dpi |
0% survival (in DBA/2J), 30% survival (in C57BL/6) |
Boon 2009 [35] |
|
Influenza A H5N1 |
HK483 (A/HK/483/97), HK486 (A/HK/486/97), HK486PB2MT (A/HK/486 PB2-627K/97) |
BALB/c |
2, 4 dpi |
0% survival (with HK483, HK486PB2MT), 25% (with HK486) |
Fornek 2009 [36] |
|
Influenza A H5N1 |
VN/1203 (Vietnam/1203/04), r1918 (H1N1) |
SvEv129 |
1, 3, 4 dpi |
0% survival (with VN/1203, r1918) |
Cilloniz 2010 [37] |
|
Mengovirus |
vMC0 (UV-inactivated mengovirus) |
BALB/c |
18 hpi |
100% survival |
Rosenthal unpub. |
|
RSV |
A2 |
BALB/c |
1, 3 dpi |
100% survival |
Janssen 2007 [38] |
|
RSV |
A2 |
B6:129PF1/J |
1 dpi |
100% survival |
Minor 2010 [39] |
|
SARS-CoV |
Urbani |
BALB/c (young, aged) |
1, 2, 5, 7 dpi |
100% survival (in young, aged) |
Baas 2008 [40] |
|
SARS-CoV |
icUrbani, icGZ02, icHC/SZ/61/03 |
BALB/c AnNHsd (young, aged) |
12 h, 1, 3 dpi |
0% survival (in aged with icHC/SZ/61/03), 40% survival (in aged with icGZ02), 100% survival (in young with all 3 virus strains, in aged with Urbani) |
Rockx 2009 [41] |
|
SARS-CoV |
MA15 |
129 |
2, 5, 9 dpi |
100% survival |
Zornetzer 2010 [42] |
|
|
|||||
|
Influenza A H1N1 |
A/CA/04/2009, MA1 (a mouse-adapted strain of A/CA/04/2009) |
BALB/c |
1, 3, 5 dpi |
0% survival (with MA1), 100% survival (with A/CA/04/2009) |
Josset in preparation |
|
|
|||||
|
* Note "dpi" refers to days post-infection. Other annotations are stated as in primary publications. The last row (below line) refers to a data set external to the compendium that was used as a test set for predictions. |
|||||
|
Chang et al. BMC Systems Biology 2011 5:202 doi:10.1186/1752-0509-5-202 |
|||||
