Characterization of the analog gene signature by known interactions and expression across pathogenicity groups. (A) Network showing known interactions among a subset of analog signature gene products related to chemokines and interferon-related signalling. Signature genes are shaded with those also encoding CXCR3 ligands in yellow and those also encoding CCR3 ligands in orange. Specific classes of molecules are indicated by shape (legend). (B) Proportion of all genes in the compendium ordered from least to greatest or greatest to least according to pathogenicity as indicated in lightly shaded regions. Genes not matching either of these patterns are counted in darkly shaded regions. (C) Proportion of analog signature genes ordered from least to greatest or greatest to least according to pathogenicity (following same color schema as part B). (D) PCC scatter plot of analog signature genes indicating the time of sample collection. (E) Model of analog signature gene expression during infections of different pathogenicities consistent with observations in this study.
Chang et al. BMC Systems Biology 2011 5:202 doi:10.1186/1752-0509-5-202