Receptor concentrations from simulations and CLV3 perturbation simulations. A-D) Study of the amount of free receptors compared with the amounts of bound receptors and free CLV3. A and C) Concentrations of free CLV3 compared with amounts of free receptors in simulations of wild type with the interference model (A) and the background distribution (C). B and D) Amounts of bound receptors compared with amounts of free receptors in simulations of wild type with the interference model (C) and the background distribution (D). E-F) Study of CLV3 over- and underexpression. The parameters s3 and kW are multiplied by a factor (presented as the abscissa). The perturbed WUS expression is then normalized with the unperturbed WUS expression (presented as the ordinate). Presented data is average and standard deviation of normalized equilibrium WUS expressions in simulations of wild type with the loss-of-signal model (E) and the interference model (F).
Sahlin et al. BMC Systems Biology 2011 5:2 doi:10.1186/1752-0509-5-2