Table 2

Identification of further targets of PdhR

Targets sorted by z-score

Targets sorted by regulatory score

ID

Gene

Regulatory score

z-score

ID

Gene

Regulatory score

z-score


b1109

ndh*

2.913

7.803

b1109

ndh*

2.913

7.803

b0091

murC$

-0.030

5.958

b0114

aceE*

2.250

5.866

b0115

aceF*

2.008

5.883

b4467

glcF$

2.181

0.275

b0114

aceE*

2.250

5.866

b0115

aceF*

2.008

5.883

b0088

murD$

-0.013

5.623

b2579

yfiD*

1.973

0.805

b0090

murG$

-0.015

4.773

b2979

glcD$

1.853

1.709

b0089

ftsW$

0.073

4.664

b4467

glcF$

1.163

0.275

b0084

ftsI$

0.140

4.556

b2975

glcA$

1.144

0.400

b0082

mraW$

-0.056

4.297

b2977

glcG$

1.056

2.315

b0087

mraY$

0.086

4.229

b2601

aroF

1.051

1.723

b0125

hpt

0.002

4.149

b3828

metR

1.035

1.449

b3613

envC

-0.005

3.938

b2976

glcB$

0.977

2.124

b0628

lipA*

-0.075

3.914

b1596

ynfM

0.927

0.007

b4052

dnaB

-0.018

3.864

b2600

tyrA

0.915

2.065

b0085

murE$

0.167

3.659

b2505

yfgH

0.820

0.425

b0822

ybiV

0.284

3.653

b0333

prpC

0.729

0.021

b2683

ygaH

-0.077

3.628

b0331

prpB

0.713

0.024

b0436

tig

-0.260

3.620

b3939

metB

0.677

2.667

b4290

fecB*

0.315

3.561

b3547

yhjX

0.668

2.931

b0083

ftsL$

0.119

3.536

b3426

glpD

0.659

0.904


Top-ranking genes with putative phylogenetically conserved binding sites of PdhR sorted according to z-scores (first four columns) and regulatory scores (last four columns). Previously known targets of PdhR are marked with "*" and new targets confirmed in this study with "$". Additionally to the new experimentally validated targets indicated in the above table, a regulation of mraZ, murF, ddlB, ftsQ, ftsA, ftsZ and lpxC by PdhR was confirmed as they are part of the operon that forms the dcw-cluster.

Göhler et al. BMC Systems Biology 2011 5:197   doi:10.1186/1752-0509-5-197

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