Additional file 2.

We investigated how the kinetic parameters governing NRP2 binding to VEGF165 and coupling to VEGFR1 and VEGFR2 influenced the steady-state concentration of free VEGF in the body. A, Effect of VEGF165 binding to NRP2; squares and triangles indicate lower and upper values of kon, respectively, taken from literature. B, Effect of NRP2 coupling to VEGF165/VEGFR2. C, Effect of VEGF165/NRP2 coupling to VEGFR2. D, Effect of NRP2 coupling to VEGFR1. In all panels, gray circles indicate baseline values taken from NRP1 interactions.

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Finley et al. BMC Systems Biology 2011 5:193   doi:10.1186/1752-0509-5-193