Box plots of the parameters corresponding to the different responses types. (A) Box plots of parameter sets leading to a transient (green) or sustained (red) response. Parameters that differ are mainly k8, k10, k11, k13 (shuttling rate from cytoplasm to nucleus, formation/dissolution of the Smad dimers, and dephosphorylation of R-Smad), and k5, k6, k14, k15, k17, k18, k19 (all related to the strengh of the feedback). (B) Box plots of parameter sets leading to a transient (green) or oscillatory (blue) response. k16, k17, k19 (dynamics of the I-Smad mRNA and I-Smad protein) and k2 (binding of TGF-β to its receptor) are key determinants of the response kind. Ranges of the uniform sampling distributions, as stated in Table S1, are indicated by grey boxes.
Cellière et al. BMC Systems Biology 2011 5:184 doi:10.1186/1752-0509-5-184