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Open Access Highly Accessed Research article

The plasticity of TGF-β signaling

Geraldine Cellière1, Georgios Fengos23, Marianne Hervé1 and Dagmar Iber23*

Author Affiliations

1 Department of Biosystems Science and Engineering (D-BSSE), Eidgenöossische Technische Hochschule Zurich (ETHZ), Mattenstrasse 26, 4058 Basel, Switzerland

2 Department of Biosystems Science and Engineering (D-BSSE) Eidgenöossische Technische Hochschule Zurich (ETHZ), Switzerland

3 Swiss Institute of Bioinformatics (SIB), Mattenstrasse 26, 4058 Basel, Switzerland

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BMC Systems Biology 2011, 5:184  doi:10.1186/1752-0509-5-184

Published: 3 November 2011

Additional files

Additional file 1:

Model_in_Cell_Designer. Systems Biology Markup Language (SBML) file of the model.

Format: XML Size: 85KB Download file

Open Data

Additional file 2:

Supplementary_Tables. Tables of the model parameters and the equations used in the model.

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Additional file 3:

Supplementary_Figures. Figures for the response classification of the parameter screen (Fig. S5), the dependance of the damping of oscillations on k2 (Fig. S6), boxplots for the parameter sets that can lead to both transient and sustained responses (Fig. S7), distribution of the maximal output value (Fig. S8), boxplots for parameters with high and low saturation value (Fig. S10), and with high and low maximal value (Fig. S9), boxplots for faithful and unfaithful parameters sets (Fig. S11), the evolution of the concentrations of all species in a representative cases (Fig. S1, S2, S3 and S4).

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Open Data