Table 3

Metabolic fluxes corresponding to the best fit of experimental data and their 99% confidence intervals

Glucose as the only substrate

Glucose with lactate

99% confidence interval

99% confidence interval

bestfit (min - max)

bestfit (min - max)

Model A


hk1

0.0026894(0.002150-0.003080)

0.152266(0.074815-0.377413)

0.01981

hk2

0.0021436(0.001710-0.002480)

0.0056939(0.0041563-0.0076078)

g6pase1

5.50E-05(2.70E-5-7.80E-5)

0.150611(0.073125-0.375565)

0.01809

g6pase2

2.13E-05(0.0-0.000066)

0.005166(0.0029064-0.0071982)

pfk1

0.003048(0.002370-0.003530)

0.0023558(0.0015063-0.0046942)

0.00345

pfk2

0.0004816(0.0-0.000950)

0.0007975(0.0006197-0.0012778)

fbpase1

0.0004446(0.000270-0.000560)

0.0013469(0.0005781-0.0023709)

0.00363

fbpase2

0.0005496(0.000330-0.000690)

0.0023329(0.00161-0.0032427)

gp

2.56E-06(1.70E-6-5.10E-6)

0.000143(5.12E-05-0.0001883)

0.00000

gs

0.0021929(0.001660-0.002680)

0.0022087(0.0018593-0.0027097)

0.00188

aldf

0.0192413(0.007480-0.022580)

0.0159083(0.0153142-0.0163931)

0.01608

aldr

0.016706(0.004480-0.020410)

0.0164349(0.0153054-0.016708)

0.01625

aldex

0.0424386(0.010420-0.056150)

0.0137425(0.0103922-0.0195718)

0.01565

g3pep

0.0064103(0.004490-0.007700)

0.258278(0.1677705-0.3394195)

0.12224

pepg3

0.0013391(0.000140-0.002370)

0.258701(0.166264-0.339572)

0.12257

pk

0.0050704(0.003910-0.006230)

0.0199774(0.0157079-0.0239355)

0.01497

lacin

1.71E-07(1.20E-7-2.60E-7)

0.231716(0.1714965-0.2686475)

0.12266

lacout

0.00507(0.003910-0.006230)

0.222326(0.1621185-0.2590095)

0.11074

pc

1.20E-07(5.70E-8-1.90E-7)

0.0204457(0.0155337-0.0233495)

0.01542

pepck

1.16E-08(5.30E-9-2.80E-8)

0.020401(0.0154933-0.0232863)

0.01530

maloa

1.85E-07(9.60E-8-3.00E-7)

0.0835934(0.048937-0.111892)

0.03396

oamal

3.80E-08(1.30E-8-8.10E-8)

0.0747156(0.0368199-0.0997713)

0.02261

cs

2.55E-07(1.30E-7-4.00E-7)

0.008922(0.0069631-0.0147641)

0.01147

citmal

1.47E-07(8.40E-8-2.30E-7)

0.0088778(0.0069227-0.0146991)

0.01135

pdh

2.75E-07(7.70E-8-5.00E-7)

0.0089212(0.0069623-0.0147633)

0.01147

g6pdh

3.87E-06(2.80E-6-7.50E-6)

0.0018986(0.0013506-0.0021492)

0.00000

p5p > s7p

0.0011849(0.000880-0.002270)

0.0006229(0.0004459-0.0007215)

0.00051

s7p > r5p

0.0011925(0.000890-0.002280)

4.35E-06(2.56E-06-2.98E-05)

0.00047

f6p > p5p

9.59E-06(4.20E-6-3.40E-5)

4.02E-05(1.17E-05-9.84E-05)

0.00000

p5p > f6p

4.93E-06(2.80E-6-2.80E-5)

0.0006793(0.0004937-0.000751)

0.00000

f6p > s7p

1.85E-05(9.20E-6-7.30E-5)

1.40E-05(4.56E-06-2.45E-05)

0.00000

s7p > f6p

9.56E-06(4.80E-6-6.60E-5)

1.65E-06(9.03E-07-8.56E-06)

0.00000

p5p-g3p

0.0006152(2.70E-4-2.83E-3)

0.0017868(0.0007706-0.0033249)

0.00036

f6p-s7p

7.69E-08(2.10E-8-7.70E-7)

1.53E-05(4.62E-06-2.78E-05)

0.00000

p5p-s7p

0.0022967(1.37E-3-7.06E-3)

1.51E-06(8.37E-07-8.16E-06)

0.00067

f6p > s7p

0.0015144(0.000850-0.001940)

0.000862(0.0002796-0.0021263)

0.00117

s7p-f6p

0.0015015(0.000850-0.001920)

0.0014894(0.0008194-0.0026708)

0.00119

f6p-g3p

0.0075338(0.002170-0.013330)

0.0164459(0.0085357-0.0352201)

0.00230

s7p-e4p

0.0003018(0.000140-0.000550)

7.81E-05(2.01E-05-0.0002102)

0.00061


The names of fluxes are given in the list of abbreviations in the text.

Marin de Mas et al. BMC Systems Biology 2011 5:175   doi:10.1186/1752-0509-5-175

Open Data