Effect of regularization strength. A) Model error Xd for all acceptable parameter sets for increasing λ, where green indicates an acceptable data fit and red an unacceptable data fit. B) Regularization error Xr for increasing λ. Note that a small λ is already sufficient to minimize parameter changes, while describing the experimental data still very well. A λ of 0.1 was selected (dashed line).
Tiemann et al. BMC Systems Biology 2011 5:174 doi:10.1186/1752-0509-5-174