Analysis of coverage of genes involved in unfolded protein response (UPR) and autophagy in PIN compared to hypergeometric and raw BIOGRID data. For the 13 GO Slim terms with the highest and lowest interactions with UPR or ATG genes in PIN, the fraction of GO Slim terms was compared for each network. We used the top 20% interactions in each network. A) The distribution of GO Slim terms suggests that for the UPR network, PIN has many fewer false positives than raw BIOGRID data (e.g. terms related to nucleus). B) The distribution of GO Slim terms suggests that for the ATG network PIN has many more true positives than the other methods and less false negatives than the raw BIOGRID data.
Brito and Andrews BMC Systems Biology 2011 5:169 doi:10.1186/1752-0509-5-169