Contrary to the centrality-lethality rule, the distribution of degree for membrane associated genes is similar or higher for non-essential compared to essential nodes. Membrane associated genes were identified in each dataset by Gene Ontology and divided into essential (black) and not-essential (red) gene sets. Each plot shows the cumulative distribution of node degree for a network constructed using interaction data from the technique specified. A) BIOGRID, B) Biochemical Activity, C) PF-PCA. Between parentheses is the number of nodes.
Brito and Andrews BMC Systems Biology 2011 5:169 doi:10.1186/1752-0509-5-169