Membrane associated interactions have a higher normalized node degree than other nodes in yeast. A) Comparison of the cumulative distribution of normalized degree for membrane associated and other nodes from different datasets. Datasets with a higher proportion of membrane associated interactions (PF-PCA and SU-2HY) have higher normalized node degree. B-D) Comparison of membrane nodes with other nodes within single datasets B) Affinity capture-MS, C) BIOGRID, D) Two hybrid used to generate interaction data. 2HY, Two hybrid; BIOGRID, raw data from BIOGRID; SU-2HY, Split-ubiquitin two hybrid; AC-MS, Affinity capture-mass spectrometry; PF-PCA, protein-fragment complementation assay. Between parentheses is the number of nodes.
Brito and Andrews BMC Systems Biology 2011 5:169 doi:10.1186/1752-0509-5-169