Table 4 

Results of the Holm test for significance level α = 0.05. 

i 
α/i 
Method 
RMSE 
Method 
RMSEm 




z_{i} 
p_{i} 
Hypothesis 
z_{i} 
p_{i} 
Hypothesis 



3 
0.017 
A717 
5.69 
1.25·10^{8} 
Rejected 
A717 
2.53 
1.14·10^{2} 
Rejected 
2 
0.025 
DASA 
3.16 
1.57·10^{3} 
Rejected 
DASA 
1.58 
1.14·10^{1} 
Accepted 


1 
0.050 
PSO 
2.53 
1.14·10^{2} 
Rejected 
DE 
1.58 
1.14·10^{1} 
Accepted 


The table summarizes the outcome of the Holm test performed on the median values of the RMSE and RMSEm results obtained by parameter estimation with the four optimization methods from artificial data. In the first test based on median values of the RMSE measure, DE is the reference method with rank i = 0. In the second test based on median values of the RMSEm measure, PSO is the reference method with rank i = 0. The hypothesis "there is no difference in performance between DE (PSO) and the ith ranked method" is rejected if the statement p_{i }<α/i holds. 

Tashkova et al. BMC Systems Biology 2011 5:159 doi:10.1186/175205095159 