Figure 5.

Category I solution for the blocked reaction ADPMAN. ADP-mannose (boxed in red) is a root no-production metabolite within RECON 1. The SMILEY solution (green arrow) involved reversal of the blocked reaction ADPMAN (red arrow). This appears plausible as an enzyme catalysing such a reaction (EC 3.7.7.28) has been described in various mammals [39] along with the finding that mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) is known to be reversible and accept sugar donors other than GTP [40].

Rolfsson et al. BMC Systems Biology 2011 5:155   doi:10.1186/1752-0509-5-155
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