Characterisation of gap filling solutions proposed by SMILEY. A) The number of SMILEY solutions proposed for each blocked reaction was not even, suggesting that it is easier to incorporate some dead-end metabolites into RECON 1 over others. Approximately 49% of the blocked reactions had a single proposed solution while 29% could be circumvented in a highly dynamic manner with twenty proposed solutions. B) 85% of the blocked reactions had SMILEY solutions composed of less than three resolving reactions.
Rolfsson et al. BMC Systems Biology 2011 5:155 doi:10.1186/1752-0509-5-155