Identification of bifurcation points in the case of carbon catabolite repression (A), or nitrogen catabolite repression (B). Dynamic regulatory map based on time-series gene expression data and interaction data that associates transcription factors with the genes they regulate, highlighting bifurcation events in the time series. Transcription factors selectively responsible for the regulation a certain subset of genes causing these bifurcations are also shown in the Figure. Each time point on the x-axis corresponds to the 1st steady state, 20 sec, 40 sec, 60 sec, 8 min, 16 min, 24 min, 32 min, 1 hr, 2 hr, 3 hr, 4 hr, 5 hr, 7 hr post-impulse and the 2nd steady state attained following release from limitation. The major paths and splits in the time series data were constructed by the genes that are assigned to these paths through the model. Each node is associated with a Gaussian distribution determining its y-axis location on the map. The area of a node is proportional to the standard deviation from the Gaussian distribution. A relatively small node implied the expression of the genes going through that node will be tightly centered around the node. Bright green nodes represent split nodes, from which multiple paths diverge.
Dikicioglu et al. BMC Systems Biology 2011 5:148 doi:10.1186/1752-0509-5-148