Hierarchical clustering of the dynamics of liberation from glucose limitation (A, B) and from ammonia limitation (C, D). The clustering of the time points (A) and the genes (B) for carbon catabolite repression and the clustering of the time points (C) and the genes (D) for nitrogen catabolite repression are presented from top to bottom of the Figure. The clustering of the genes resulted in two major clusters (B) in the case of carbon catabolite repression (indicated in red and blue) and three major clusters (D) in the case of nitrogen catabolite repression; a similarity distance of 0.5 was used as the threshold. with the selected distance metric, as the Pearson correlation coefficient. The individual time points in the dynamic scale arranged into clusters forming distinct phases in which the transcriptome response was observed to be similar.
Dikicioglu et al. BMC Systems Biology 2011 5:148 doi:10.1186/1752-0509-5-148