Integrating expression data with a prototypic network model. A. Prototypic network model. Production of metabolite E is the metabolic objective (reaction 9). Reactions 4 and 6 are catalyzed by a single enzyme. Reactions 5 and 7 require enzymes composed of two necessary subunits. Reaction 8 can be catalyzed by either of two isozymes. B - D display the results of integrating expression data in Tables 3 - 5. Red indicates that a gene (reaction) is expressed (active).
Jensen et al. BMC Systems Biology 2011 5:147 doi:10.1186/1752-0509-5-147