TIGER platform overview. TIGER converts Boolean rules to MILPs. Rules are first simplified by substitution and converted into a system of linear inequalities. The rules are optionally attached to a COBRA model by coupling indicators of reaction participation (Ri) to the reaction flux vi. In addition to serving as a platform for developing new algorithms, TIGER models can be integrated with high-throughput expression data to generate context-specific models using variations on the GIMME, iMAT, and MADE algorithms.
Jensen et al. BMC Systems Biology 2011 5:147 doi:10.1186/1752-0509-5-147