The model predictions for Ca2+ current in response to membrane potential shift. The model predictions for Ca2+ current amplitude shown as a function of extracellular Ca2+ concentration and the initial membrane potential values before the voltage shift was applied. (A) The dependence of Ca2+ current amplitude on the transmembrane potential alterations is calculated for different extracellular Ca2+ concentrations. (B) The graph shows the Ca2+ current amplitude dependence on the initial values of the potential when the depolarising voltage shift was applied. The model shows that the ciliary system properties are reasonably conserved under significant variations of extracellular Ca2+ and over a wide range of membrane potential values.
Kotov et al. BMC Systems Biology 2011 5:143 doi:10.1186/1752-0509-5-143