Table 1

Prediction of the most significant pathways and networks unique for fenofibrate.

GeneGO Pathway Maps

pValue

GeneGo Toxicity Networks

pValue


Development: Growth hormone signaling via PI3K/AKT and MAPK cascades

1.152e-10

Blood coagulation: Coagulation factors. Plasminogen signaling

1.696e-08

Development: IGF-RI signaling

1.757e-08

Signal transduction: Janus kinase 2 (protein tyrosine kinase)

6.223e-08

Cytokine production by Th17 cells in CF

2.043e-08

Proliferation: Lymphocyte proliferation_STATs

2.808e-07

Cell adhesion: ECM remodeling

2.142e-08

Inflammation: SOCS3 in JAK-STAT cascade

4.345e-07

Cell adhesion: Chemokines and adhesion

2.233e-08

Inflammation: Kallikreins signaling

4.432e-07

Immune response : IL-4 - antiapoptotic action

3.753e-08

Inflammation: SERPINA3 regulation

6.102e-07

Transcription: Androgen Receptor nuclear signaling

7.793e-08

Signal transduction: IL-6R signaling ; hemopexin

9.601e-07

Transcription: Receptor-mediated HIF regulation

3.440e-07

Signal transduction: IL-6R signaling; APCS

9.601e-07

Cell adhesion: PLAU signaling

3.440e-07

Signal transduction : IL-6R signaling ; haptoglobin

1.478e-06

Immune response: IL-6 signaling pathway

5.856e-07

Proliferation: Positive regulation, HGF, CRIPTO, CCL14, IP10 signaling

2.302e-06


Unique fenofibrate targets (from prediction analysis) were employed to GeneGo Pathway Maps and GeneGo Toxicity Networks. The 10 most significant pathways maps and toxicity networks are shown.

Kleemann et al. BMC Systems Biology 2011 5:125   doi:10.1186/1752-0509-5-125

Open Data