Open Access Highly Accessed Research article

A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis

Robert Kleemann1*, Svetlana Bureeva3, Ally Perlina3, Jim Kaput45, Lars Verschuren12, Peter Y Wielinga1, Eva Hurt-Camejo6, Yuri Nikolsky3, Ben van Ommen2 and Teake Kooistra1

Author Affiliations

1 Metabolic Health Research, TNO, Zernikedreef 9, Leiden, 2333 CK, The Netherlands

2 Microbiology and Systems Biology, TNO, Utrechtseweg 48, Zeist, 3704 HE, The Netherlands

3 GeneGo, Inc., 5901 Priestly Drive, Carlsbad, CA 92008, USA

4 Division of Personalized Nutrition and Medicine FDA, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA

5 Nestle Institute of Health Sciences, EPFL Campus Bâtiment G at Quartier de l'Innovation, Lausanne, 1015, Switzerland

6 Cardiovascular & Gastrointestinal Innovative Medicines Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 43183, Sweden

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BMC Systems Biology 2011, 5:125  doi:10.1186/1752-0509-5-125

Published: 12 August 2011

Additional files

Additional file 1:

Differential in vivo effects of cardiovascular drugs on plasma lipids.

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Additional file 2:

Lists of potential targets obtained from the hepatic gene expression profile and lists of putative targets predicted from the chemical structure.

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Additional file 3:

Differential effect of cardiovascular drugs on immune cell recruitment/chemotaxis.

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