A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis
1 Metabolic Health Research, TNO, Zernikedreef 9, Leiden, 2333 CK, The Netherlands
2 Microbiology and Systems Biology, TNO, Utrechtseweg 48, Zeist, 3704 HE, The Netherlands
3 GeneGo, Inc., 5901 Priestly Drive, Carlsbad, CA 92008, USA
4 Division of Personalized Nutrition and Medicine FDA, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
5 Nestle Institute of Health Sciences, EPFL Campus Bâtiment G at Quartier de l'Innovation, Lausanne, 1015, Switzerland
6 Cardiovascular & Gastrointestinal Innovative Medicines Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 43183, Sweden
BMC Systems Biology 2011, 5:125 doi:10.1186/1752-0509-5-125Published: 12 August 2011
Additional file 1:
Differential in vivo effects of cardiovascular drugs on plasma lipids.
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Additional file 2:
Lists of potential targets obtained from the hepatic gene expression profile and lists of putative targets predicted from the chemical structure.
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