Table 1

The inferred recurrent regions of CNV in the four breast cancer datasets.

Cytoband Location

Chr

Start(Mb)

End (Mb)

Size (Mb)

Gain/Loss

Important genes


chr3q26.31-q27.1

3

173.95

185.91

11.96

G

ECT2, PIK3CA, PSMD2, CLCN2, POLR2H


chr4p16.3

4

0.69

1.95

1.26

G

CTBP1, TACC3


chr5q35.2-q35.4

5

173.41

179.09

5.69

G

GRK6, DDX41


chr8p21.2-p12

8

23.59

30.70

7.11

L

CLU


chr8q24.3

8

143.54

146.25

2.71

G

NRBP2


chr11q13.1-q13.4

11

64.54

71.59

7.05

G

MAP3K11, ADRBK1, RPS6KB2, LRP5, CPT1A


chr12q24.23-q24.33

12

120.70

122.32

1.62

G


chr16p13.4

16

2.02

2.66

0.64

G

DCI, PDPK1


chr16q12.2-q22.1

16

54.25

69.11

14.87

G

POLR2C, KIFC3, CSNK2A2, GOT2, CDH5, PSKH1, PSMB10, VPS4A,


chr16q22.3-q24.3

16

82.56

88.62

6.06

G

GALNS


chr20q11.1-q11.23

20

28.24

36.99

8.75

G

TPX2, APBA2BP, E2F1, EIF2S2, AHCY, GSS, PROCR, RBM39, SCAND1, DLGAP4, GHRH, BLCAP


chr20q13.12-q13.13

20

44.43

49.01

4.58

G

ARFGEF2, CSE1L


The important genes include known oncogenes, known tumor suppressors, and the genes that, when silenced, reduced cell viability by more than 50% based on our siRNA experiments.

Tran et al. BMC Systems Biology 2011 5:121   doi:10.1186/1752-0509-5-121

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