Table 5

Key electron sinks that compete with H2 production**

Electron Sink

Pathway

Reaction

Responsible Genes


PHB

Butanoate Metabolism

RXN0589

RSP0382, RSP1257

H2S

Sulfur Metabolism

RXN0866

RSP1942

Glycogen

Starch & Sucrose Metabolism

RXN0849

RSP2887

Formate

One Carbon Pool by Folate

RXN0323

RSP0944

Glycerate

Glycerolipid Metabolism

RXN0030

RSP1292, RSP1507, RSP3740, RSP4003, RSP2372

4-Coumarate

Nitrogen Metabolism

RXN0495

RSP3574

Methanethiol

Cysteine & Methionine Metabolism

RXN1096

RSP1851

4-Aminobutyraldehyde*

Glycolysis/Gluconeogenesis

RXN0031

RSP4003, RSP3740, RSP2372, RSP1507, RSP1292

Chitobiose*

Amino Sugar and Nucleotide Sugar Metabolism

RXN0040

RSP2941

D-1-Aminopropan-2-ol O-phosphate*

Cobalamin Metabolism

RXN0653

RSP0430

Heme*

Heme Metabolism

RXN0632

RSP1197

Ethanolamine*

Glycerophospholipid Metabolism

RXN0378

RSP0113


*Competitors for sub-optimal growth conditions only.

** Secretion of central metabolism intermediates pyruvate, fumarate, and malate were blocked, assuming that cells are programmed to reuse these compounds as carbon sources even after secretion. This was based on observations with batch cultures [3], but might not hold true for continuous cultures.

Imam et al. BMC Systems Biology 2011 5:116   doi:10.1186/1752-0509-5-116

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