Additional file 4.

Figure S1. Clinical heterogeneity: Influence of timing on the generation of self-reacting T-cells in the dynamics of the immune system. Four simulations (over 5 years) of the same model (same parameters and initial conditions) are presented for four different seeds generating the naïve Teff and Treg populations. We used a parameter configuration that allows the generation of autoimmune dynamics (αR = 0.25). Left: Dynamics of activated Teff cells. Right: Evolution along time of the reversible, irreversible and total damage.

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Vélez de Mendizábal et al. BMC Systems Biology 2011 5:114   doi:10.1186/1752-0509-5-114