Effects of interaction strengths on the stability of the dynamic network with different interaction matrix (PA → 1) Figure 2 demonstrates the evolutionary dynamics of a network with interaction matrix [1 0; 0 1], k=4, and initial populations of type A and type C cells are set as 9900 and 100 in a total population of 10000 cells, based on previously published experimental results. The intensity of selection ω equals to 0.01. In the left part of Figure 2 (Left), X axis represents the variable PA, the ratio of type A cellular population over the total population. The Y axis represents the evolutionary rate of type A cellular population denoted as ṖA. The red star is the initial status of PA. At the initial status, ṖA is positive, making PA increase until PA reaches 1 where ṖA decreases to 0. In the right part of Figure 2 (Right), the simulation results demonstrate that population of type A cells increases until it dominates the whole population within 300 generations.
Wang et al. BMC Systems Biology 2010 4(Suppl 1):S5 doi:10.1186/1752-0509-4-S1-S5