Table 3

MODY characteristics

MODY type

Gene deficiency

Prevalence⁽¹⁾

Treatment^(1,2)

Simulated mean/std of onset age

Simulated mean/std insulin

1

Hnf-4α

Uncommon

Oral medication or insulin

10.3/1.2

0.18/0.02

2

glycokinase

Common

Diet and exercise

4.5/0.3

0.26/0.005

3

Hnf-1α

Most common

Oral medication or insulin

24.0/8.1

0.24/0.08

4

Pdx1

Rare

Oral medication or insulin

22.6/11.0

0.22/0.11

5

Hnf-1β

Rare

Insulin

9.3/0.4

0.08/0.004

Observed and simulated characteristics of the five major MODY types. The absolute magnitude of the simulated values is not as important as the relative values. The standard deviation in the age of onset is much larger for MODY3 and MODY4, which should be reflected in a range of onset ages in epidemiological data. Mean and standard deviation of the insulin levels is related to the severity of the disease. Data for "Prevalence" from [42,44].

Bosl and Li BMC Systems Biology 2010 4:93   doi:10.1186/1752-0509-4-93