Integrated pathway diagram of innate immune and macrophage activation pathways. The modified Edinburgh Pathway Notation (mEPN) scheme is used to describe the interactions of signalling pathways active in the macrophage. A total of 2,172 components in this network are connected by 2,553 edges. Components include 496 unique proteins, the complexes formed between them (412), 181 genes/DNA/promotor regions, in addition to other molecular species (e.g. pathogens, drugs, RNA) and the nodes representing the processes in which the components are involved. Components are arranged to reflect the location in which they are active and background colour is used to distinguish between different sub-cellular locations.
Raza et al. BMC Systems Biology 2010 4:63 doi:10.1186/1752-0509-4-63