Figure 1.

Pathway construction workflow. A workflow diagram summarizing the main stages of pathway assembly from concept to final diagram. Blue boxes portray the pathway construction phase. Each phase embodies a number of tasks (shown as lilac boxes or yellow-ellipses for data storage and processing), which when completed lead to progression towards the next stage of pathway construction (connected by green arrows). Red arrows indicate feedback to a previous construction phase. Lilac boxes describe the construction steps required pre-pathway assembly, whereas green boxes are linked to post-construction phases and describe the possible applications of the constructed and validated pathway diagram.