Reduced model of cell metabolism. Schematic representation of ATP generation pathways via aerobic glycolysis (glycolysis + pyruvate reduction to lactate) and oxidative phosphorylation (glycolysis + mitochondrial respiration). The variable fG, denotes the glucose uptake rate, fL and fM, the components of the glucose uptake routed towards lactate excretion and respiration, respectively, and fATP the ATP production rate. Intermediate substrates of glucose catabolism are also used in a third process accounting for the production of precursor metabolites needed in anabolic processes (fP). The pathways considered in our model are shown in the gray-shaded area, while fP is treated as constant.
Vazquez et al. BMC Systems Biology 2010 4:58 doi:10.1186/1752-0509-4-58