Table 3

Partial flux control coefficients for succinate-CoA ligase (r33), fumarate hydratase (r34), succinate dehydrogenase (r40), and the malic enzyme (r43)

r33

r34

r40

r43


Partial flux control coefficient through

Flux control coefficient

Partial flux control coefficient through

Flux control coefficient

Partial flux control coefficient through

Flux control coefficient

Partial flux control coefficient through

Flux control coefficient





Enzyme

ATPin

SUCin

SUCCOAin

ADPin

MALin

FUMin

NADin

SUCin

FUMin

NADHin

PYRin

NADPin

MALin

NADPHin


r1

-0.005

-0.196

0.018

-0.002

-0.185

-0.598

0.414

-0.185

0.000

0.126

-0.247

-0.063

-0.185

-0.060

-0.127

0.085

-0.227

-0.328

r2

-0.003

0.003

-0.001

-0.001

-0.002

0.089

-0.091

-0.002

0.000

-0.002

0.055

-0.055

-0.002

-0.025

0.017

-0.013

0.030

0.009

r3

-0.003

-0.009

0.000

-0.002

-0.014

0.061

-0.075

-0.014

0.000

0.006

0.045

-0.064

-0.014

-0.032

0.011

-0.009

0.019

-0.010

r4

-0.004

-0.012

0.000

-0.002

-0.018

0.077

-0.094

-0.018

0.000

0.008

0.056

-0.081

-0.018

-0.040

0.014

-0.011

0.024

-0.013

r5

-0.001

-0.002

0.000

0.000

-0.002

0.011

-0.013

-0.002

0.000

0.001

0.008

-0.011

-0.002

-0.005

0.002

-0.002

0.003

-0.002

r6

-0.009

-0.028

0.000

-0.005

-0.042

0.178

-0.220

-0.042

-0.001

0.018

0.132

-0.191

-0.042

-0.093

0.031

-0.025

0.056

-0.032

r7

0.000

0.000

0.000

0.000

-0.001

0.003

-0.003

-0.001

0.000

0.000

0.002

-0.003

-0.001

-0.001

0.000

0.000

0.001

0.000

r8

0.000

-0.006

0.001

0.000

-0.006

-0.026

0.020

-0.006

0.000

0.004

-0.012

0.002

-0.006

-0.021

0.002

0.004

0.003

-0.013

r9

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

r10

0.036

-0.544

0.064

0.019

-0.425

-3.145

2.720

-0.425

0.003

0.349

-1.624

0.847

-0.425

0.315

-0.631

0.449

-1.131

-0.998

r11

0.002

-0.025

0.003

0.001

-0.019

-0.143

0.123

-0.019

0.000

0.016

-0.074

0.038

-0.019

0.014

-0.029

0.020

-0.051

-0.045

r12

-0.012

-0.047

0.001

-0.006

-0.065

0.196

-0.261

-0.065

-0.001

0.030

0.156

-0.250

-0.065

-0.125

0.033

-0.028

0.060

-0.060

r13

0.002

0.006

0.000

0.001

0.009

-0.034

0.043

0.009

0.000

-0.004

-0.026

0.038

0.009

0.019

-0.006

0.005

-0.011

0.006

r14

-0.026

-0.090

0.002

-0.013

-0.127

0.422

-0.549

-0.127

-0.002

0.058

0.328

-0.510

-0.127

-0.253

0.073

-0.060

0.131

-0.108

r15

0.011

0.032

0.000

0.006

0.048

-0.209

0.257

0.048

0.001

-0.020

-0.153

0.221

0.048

0.109

-0.037

0.030

-0.066

0.035

r16

-0.017

-0.050

0.000

-0.009

-0.075

0.322

-0.398

-0.075

-0.001

0.032

0.238

-0.344

-0.075

-0.170

0.057

-0.046

0.102

-0.056

r17

0.000

0.000

0.000

0.000

0.000

-0.001

0.001

0.000

0.000

0.000

0.000

0.000

0.000

-0.001

0.000

0.000

0.000

0.000

r18

-0.019

0.532

-0.058

-0.010

0.446

2.173

-1.728

0.446

-0.001

-0.342

1.031

-0.243

0.446

1.168

0.052

-0.310

0.093

1.003

r19

0.061

-0.324

0.048

0.032

-0.182

-2.522

2.340

-0.182

0.004

0.208

-1.397

1.004

-0.182

-1.099

0.004

0.360

0.007

-0.729

r20

0.000

0.000

-0.001

0.000

-0.001

0.004

-0.005

-0.001

0.000

0.000

0.003

-0.004

-0.001

-0.002

0.000

-0.001

-0.001

-0.004

r21

0.000

0.000

0.000

0.000

0.000

-0.001

0.001

0.000

0.000

0.000

-0.001

0.001

0.000

0.000

0.000

0.000

0.000

0.000

r22

0.002

0.751

-0.074

0.001

0.680

2.787

-2.107

0.680

0.000

-0.482

1.258

-0.096

0.680

0.069

0.579

-0.398

1.037

1.287

r23

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

0.000

-0.001

0.000

0.000

0.001

0.000

r24

0.001

0.003

0.000

0.000

0.004

-0.018

0.022

0.004

0.000

-0.002

-0.013

0.019

0.004

0.009

-0.003

0.003

-0.006

0.003

r25

0.000

-0.002

0.000

0.000

-0.002

-0.012

0.010

-0.002

0.000

0.001

-0.006

0.003

-0.002

-0.007

0.001

0.002

0.001

-0.004

r26

0.000

0.000

0.000

0.000

0.000

-0.002

0.002

0.000

0.000

0.000

-0.001

0.001

0.000

-0.001

0.000

0.000

0.000

0.000

r27

0.000

0.000

0.000

0.000

0.000

0.007

-0.006

0.000

0.000

0.000

0.004

-0.003

0.000

-0.002

0.001

-0.001

0.002

0.000

r28

0.000

0.005

-0.001

0.000

0.005

0.023

-0.019

0.005

0.000

-0.003

0.011

-0.003

0.005

0.018

-0.001

-0.003

-0.002

0.011

r29

0.004

0.146

-0.008

0.002

0.144

0.584

-0.440

0.144

0.000

-0.094

0.263

-0.024

0.144

0.230

-0.018

-0.083

-0.032

0.098

r30

-0.001

0.010

-0.001

0.000

0.008

0.077

-0.069

0.008

0.000

-0.006

0.041

-0.027

0.008

0.009

0.003

-0.011

0.005

0.005

r31

-0.002

0.018

-0.001

-0.001

0.014

0.141

-0.127

0.014

0.000

-0.011

0.076

-0.050

0.014

0.016

0.005

-0.020

0.009

0.009

r32

-0.001

0.010

-0.001

-0.001

0.008

0.084

-0.075

0.008

0.000

-0.007

0.045

-0.030

0.008

0.009

0.003

-0.012

0.005

0.005

r33

-0.001

-0.924

-0.007

0.000

0.068

-0.755

0.823

0.068

0.000

0.592

-0.492

-0.033

0.068

0.014

0.000

0.108

-0.001

0.121

r34

-0.001

0.071

-0.007

0.000

0.063

-0.703

-0.234

0.063

0.000

-0.046

0.139

-0.030

0.063

0.013

0.000

0.100

-0.001

0.112

r35

0.001

0.042

-0.002

0.001

0.041

0.168

-0.126

0.041

0.000

-0.027

0.075

-0.007

0.041

0.066

-0.005

-0.024

-0.009

0.028

r36

0.013

0.503

-0.026

0.007

0.497

2.012

-1.515

0.497

0.000

-0.323

0.904

-0.084

0.497

0.793

-0.061

-0.287

-0.109

0.337

r37

0.000

-0.013

0.015

0.000

0.002

-0.002

0.004

0.002

0.000

0.008

-0.002

-0.004

0.002

0.001

0.000

0.000

0.000

0.002

r38

-0.001

-0.014

0.002

0.000

-0.013

-0.070

0.057

-0.013

0.000

0.009

-0.034

0.012

-0.013

-0.049

0.003

0.010

0.005

-0.031

r39

0.003

-0.061

0.030

0.002

-0.027

-0.360

0.334

-0.027

0.000

0.039

-0.199

0.133

-0.027

-0.034

-0.007

0.051

-0.013

-0.003

r40

-0.001

0.119

-0.011

-0.001

0.106

-1.177

1.284

0.106

0.000

-0.076

-0.766

-0.051

0.106

0.022

-0.001

0.168

-0.001

0.188

r41

-0.040

-0.493

0.062

-0.021

-0.492

-2.273

1.782

-0.492

0.001

0.316

-1.064

0.255

-0.492

-1.765

0.133

0.324

0.239

-1.069

r42

0.004

-0.032

0.022

0.002

-0.004

-0.235

0.231

-0.004

0.000

0.021

-0.138

0.112

-0.004

0.053

-0.013

0.034

-0.023

0.050

r43

-0.006

0.421

-0.043

-0.003

0.369

1.774

-1.405

0.369

-0.001

-0.270

0.839

-0.199

0.369

-0.030

0.006

-0.253

0.011

0.735

r44

0.001

-0.051

0.011

0.001

-0.038

-0.239

0.201

-0.038

0.000

0.032

-0.120

0.049

-0.038

-0.100

-0.002

0.034

-0.004

-0.073

r45

0.000

0.013

-0.001

0.000

0.011

0.053

-0.042

0.011

0.000

-0.008

0.025

-0.006

0.011

0.028

0.001

-0.007

0.002

0.024

r46

0.009

0.260

-0.033

0.005

0.241

1.285

-1.044

0.241

-0.001

-0.167

0.623

-0.214

0.241

0.888

-0.052

-0.183

-0.094

0.558

r47

-0.001

-0.043

0.004

-0.001

-0.041

-0.132

0.091

-0.041

0.000

0.028

-0.055

-0.014

-0.041

-0.013

-0.028

0.019

-0.050

-0.072

r48

0.001

-0.002

-0.005

0.000

-0.005

0.022

-0.027

-0.005

0.000

0.001

0.016

-0.023

-0.005

-0.013

-0.003

-0.003

-0.005

-0.024

r49

0.001

0.022

-0.003

0.001

0.022

0.107

-0.086

0.022

0.000

-0.014

0.051

-0.015

0.022

0.080

-0.005

-0.015

-0.010

0.050


Partial flux control coefficients are only shown for metabolites with non-zero elasticities. The sum of the partial flux control coefficients over all intermediates equals the flux control coefficient. For the control of an enzyme over its own flux, the flux control coefficient equals the sum of the partial flux control coefficients plus one.

Maier et al. BMC Systems Biology 2010 4:54   doi:10.1186/1752-0509-4-54

Open Data