Open Access Highly Accessed Research article

Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma

Huiqing Liu111, Angela R Brannon2, Anupama R Reddy1, Gabriela Alexe3, Michael W Seiler1, Alexandra Arreola2, Jay H Oza4, Ming Yao4, David Juan5, Louis S Liou56, Shridar Ganesan4, Arnold J Levine7, WK Rathmell28* and Gyan V Bhanot110479*

Author Affiliations

1 BioMaPS Institute, Rutgers University, Piscataway, NJ 08854, USA

2 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA

3 Broad Institute of MIT and Harvard, 7 Cambridge Center, MA, 02142, USA

4 Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA

5 Department of Pathology, Boston University Medical School, Boston, MA 02118, USA

6 Cambridge Health Alliance, Harvard Medical School, Cambridge MA 02139, USA

7 Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA

8 Departments of Medicine and Genetics, University of North Carolina, Chapel Hill, NC 27599, USA

9 Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA

10 Department of Physics, Rutgers University, Piscataway, NJ 08854, USA

11 Current address: Bioinformatics, Centocor R&D Inc, 145 King of Prussia Road, Radnor, PA 19087, USA

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BMC Systems Biology 2010, 4:51  doi:10.1186/1752-0509-4-51

Published: 27 April 2010

Additional files

Additional file 1:

Targets of upregulated microRNA: This file contains the list of mRNA targets of upregulated microRNAs in ccRCC compared to normal kidney as identified by our method.

Format: XLSX Size: 10KB Download file

Open Data

Additional file 2:

Targets of downregulated microRNA: This file contains the list of mRNA targets of downregulated microRNAs in ccRCC compared to normal kidney as identified by our method.

Format: XLSX Size: 18KB Download file

Open Data