Table 1 |
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|
Effects of noise in Blimp-1 protein expression on the steepness and position of the LPS dose response curves. |
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|
% plasma Cells |
IgM Secretion |
|||
|
|
||||
|
Blimp-1 noise |
nH |
ED50 |
nH |
ED50 |
|
|
||||
|
1.423 |
1.253 |
1.074 |
1.260 |
1.100 |
|
1.928 |
1.201 |
0.755 |
1.188 |
0.843 |
|
3.482 |
0.959 |
0.570 |
1.023 |
0.650 |
|
|
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|
Note: The quantitative effects of altering Blimp-1 noise level were evaluated for the dose response curves of percentage of plasma cell formation and IgM secretion presented in Figure 7. Blimp-1 noise level is expressed as the coefficient of variation of Blimp-1 protein abundance. The default parameter values of the model generate a coefficient of variation of 1.928. The lower (higher) noise level of 1.423 (3.482) was obtained by increasing (decreasing) Blimp-1 transcription rate constant (k13) and decreasing (increasing) Blimp-1 translation rate constant (k15) by 5-fold, which kept the deterministic steady-state level of Blimp-1 protein unchanged. nH, Hill coefficient; ED50, concentration of LPS (μg/ml) producing 50% of the maximum response. |
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|
Zhang et al. BMC Systems Biology 2010 4:40 doi:10.1186/1752-0509-4-40 |
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