Table 2

Pathways significantly correlated with the instability index.

Name

Size

NES

P value


Negative correlation


G1 to S cell cycle reactome

150

-1.87

0.0000

Nuclear membrane

208

-1.72

0.0023

Negative regulation of progression through cell cycle

183

-1.64

0.0024

Mitosis

261

-1.82

0.0044

M phase of mitotic cell cycle

262

-1.81

0.0044

Protein kinase inhibitor activity

41

-1.71

0.0046

G1 pathway

68

-1.85

0.0046

Cell cycle pathway

57

-1.85

0.0066

Mitotic cell cycle

427

-1.76

0.0069

Kinase inhibitor activity

42

-1.72

0.0070

Protein amino acid-ribosylation

30

-1.92

0.0071

Eicosanoid synthesis

29

-1.79

0.0072

P53 pathway

43

-1.77

0.0085

Notch pathway

17

-1.70

0.0086

Cell cycle

176

-1.82

0.0087

Integrin mediated cell adhesion

222

-1.73

0.0089

RNA helicase activity

41

-1.78

0.0097

Positive correlation


UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

21

1.84

0.0000

Adrenoceptor activity

25

1.94

0.0017

Amine receptor activity

47

1.88

0.0018

Beta-1,3-galactosyltransferase activity

25

1.94

0.0020

Mono amine GPCRS

45

1.88

0.0038

Glutamate metabolism

51

1.78

0.0042

Neuromuscular junction development

15

1.76

0.0057

Serotonin receptor activity

22

1.81

0.0057

Oxidoreductase activity, acting on the CH-CH groups of donors, oxygen as acceptor

15

1.72

0.0064


Gene set enrichment analysis was performed using Pearson correlation between expression level and instability index as a ranking metric. Significant gene sets were identified by permutation-based nominal p value (p < 0.01). NES, normalized enrichment score.

Lee et al. BMC Systems Biology 2010 4:29   doi:10.1186/1752-0509-4-29

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